Endocrine Abstracts

Background: Patients with adrenal insufficiency (AI) require glucocorticoid replacement therapy. Current Endocrine Society guidelines recommend thrice-daily hydrocortisone (15-25mg) or once-daily prednisolone (3-5mg). Concerns around prednisolone use have been based on evidence using higher doses. We have been using low-dose (2-4mg) once-daily prednisolone since 2014 for glucocorticoid replacement in adult patients with AI. This study aimed to compare the effe...

Background: Adrenal Insufficiency (AI) is a life-threatening disorder caused by dysfunction of the adrenal axis (primary AI) or of the hypothalamic-pituitary-adrenal axis (secondary AI). Both result in glucocorticoid deficiency, requiring life-long replacement, with additional mineralocorticoid replacement required in primary AI. However, accurately reproducing the endogenous circadian and ultradian rhythm of cortisol secretion is challenging. Current Endocrin...

The term Leaky Gut Syndrome (LGS) describes a collection of a range of symptoms, including abdominal pain, bloating, recurring diarrhoea, bloody stools and weight loss, when a diagnosis has not been, or cannot be, made. It can be associated with inflammatory bowel disease (IBD), celiac disease, chemotherapy and radiation therapies, and endocrine conditions including obesity and diabetes. The common underlying features of LGS are gut inflammation and an increase in gastrointest...

Background: On the basis of prior large epidemiologic and retrospective studies on treatment-related side effects, it appears that there are sex-based differences in the epidemiology of NENs and treatment-related side effects. The purpose of this study was to examine sex differences in incidence, diagnoses present during hospital stay, and mortality among patients with NENs.Methods: The NIS database was used to define an unweighted sample of patients wit...

Background: As persistant organic pollutants, polychlorinated biphenyls (PCBs) are widespread in environment worldwide. Serum PCBs and nuclear factor erythroid 2-related factor 2 (NRF2) are associated with glucose homeostasis damage in the general population. However, there is a lack of epidemiological evidence on the interaction between serum PCBs and NRF2 gene in relation to glucose homeostasis damage.Objectives: We aimed to explore the intera...

Major adverse cardiac events (MACE) are the leading cause of death among hip fracture patients. This study aimed to: (1) identify hip fracture subphenotypes using LCA and (2) evaluate the prognosis of the hip fracture subphenotypes on CVE-related outcomes in two extensive hip fracture cohorts from Hong Kong (HK CDARS; n=78,417) and the United Kingdom (UK THIN; n=27,948), employing both the conventional cohort (between-individual comparison) design and the sel...

Objective: Studies have demonstrated that patients with acromegaly have compromised bone health and an increased risk of vertebral fractures (VFs). However, the prevalence of VFs in Chinese patients with acromegaly has not been investigated by far. This study aimed to evaluate the prevalence and determinants of VFs in patients with acromegaly in a tertiary hospital in China.Methods: We enrolled patients diagnosed with acromegaly consecutively at West Chi...

Background: Bariatric surgery, dietary restriction and gut hormones treatment for obesity, lead to distinctive changes in weight-loss maintenance and glycaemia. We previously showed that Roux-en-Y Gastric Bypass (RYGB) and Very-Low-Calorie-Diet (VLCD) were superior in weight-loss, compared to a tripeptide hormone infusion of G lucagon-like Peptide-1, O xyntomodulin and P eptide-YY over a month (GOP, infused at doses to replicate their peak post-prandial concen...

Introduction: Acromegaly is a disorder caused by excessive secretion of growth hormone, often due to pituitary masses. The first step in treatment is transsphenoidal surgery. Cabergoline, somatostatin receptor ligands or pegvisomant may be used in patients with an inadequate response after surgery. Finally, radiotherapy may be used in patients with inadequate response to medical treatment.Methods: In this retrospective study, data of 89 patients (59 fema...

Objective: To summarise and analyze the pathogenesis, clinical risk assessment, and treatment of venous thromboembolic events (VTE) associated with Cushing syndrome (CS), and to improve clinicians’ understanding of this complication.Methods: The clinical diagnosis and treatment of 3 patients with Cushing disease (CD) combined with pulmonary embolism were reviewed, and relevant literature at home and abroad was reviewed.Results...